Butternut Squash Chicken Alfredo (Printer-Friendly)

Comforting casserole with chicken, roasted butternut squash, pasta, and creamy Alfredo sauce, topped with bubbling cheese.

# What You Need:

→ Proteins

01 - 2 cups cooked chicken breast, shredded or diced

→ Vegetables

02 - 3 cups butternut squash, peeled and cubed (about 1 medium)
03 - 2 cups baby spinach (optional)

→ Pasta

04 - 12 ounces penne or rigatoni, uncooked

→ Alfredo Sauce

05 - 3 tablespoons unsalted butter
06 - 3 cloves garlic, minced
07 - 1½ cups heavy cream
08 - 1 cup whole milk
09 - 1½ cups freshly grated Parmesan cheese
10 - ¼ teaspoon ground nutmeg
11 - Salt and freshly ground black pepper, to taste

→ Topping

12 - 1½ cups shredded mozzarella cheese
13 - ¼ cup fresh basil or parsley, chopped (garnish)

# How to Cook:

01 - Preheat oven to 400°F. Toss butternut squash cubes with olive oil, salt, and pepper. Spread on a parchment-lined baking sheet and roast for 20–25 minutes until tender and slightly golden. Set aside and reduce oven temperature to 375°F.
02 - Boil pasta in a large pot of salted water until just al dente. Drain and set aside.
03 - Melt butter over medium heat in a saucepan. Add minced garlic and sauté for 1 minute until fragrant. Stir in heavy cream and whole milk, bringing to a gentle simmer. Add Parmesan cheese and nutmeg while whisking until sauce is smooth and thickened. Season with salt and freshly ground black pepper.
04 - In a large mixing bowl, gently combine cooked pasta, roasted butternut squash, chicken, baby spinach (if using), and Alfredo sauce.
05 - Transfer the mixture to a greased 9x13-inch baking dish. Top evenly with shredded mozzarella cheese. Bake at 375°F for 20–25 minutes until cheese is melted, bubbly, and lightly golden.
06 - Remove from oven and let rest for 5 minutes. Garnish with chopped fresh basil or parsley before serving warm.

# Expert Advice:

01 -
  • Baked until the cheese is gloriously golden, this casserole is pure comfort layered with creamy textures and roasted flavors.
  • It wins over picky eaters and busy weeknights alike—I kept reaching for seconds the first time I shared it with friends.
02 -
  • The first time I rushed the sauce, it split—always add dairy slowly and avoid letting it boil hard.
  • Switching from store-bought shredded cheese to hand-grated Parmesan made all the difference in silkiness.
03 -
  • Tent the casserole loosely with foil if the cheese gets too brown before the middle is hot.
  • An extra splash of pasta water makes the sauce cling to every bite if your mix looks a bit dry.
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